Which symptom is commonly associated with uremia in advanced CKD?

• A. Itching
• B. Nausea
• C. Decreased appetite
• D. Weight loss

Answer: (B)

Uremia results from the buildup of waste products in the blood when the kidneys fail, and those toxins affect multiple body systems. The gastrointestinal tract is particularly sensitive to this toxin load, leading to nausea as a direct and common symptom of advanced CKD. When nausea is present, patients often eat less, which explains accompanying weight loss and also contributes to malnutrition seen in later-stage kidney disease. Itching can occur in CKD due to mineral disturbances, but it’s not as universally tied to the toxin accumulation driving uremia itself, and decreased appetite or weight loss are more often downstream effects of the nausea and overall illness. So nausea best fits as the symptom most commonly associated with uremia in advanced CKD.