Which statement best describes adherence to immunosuppressant therapy after kidney transplantation?

• A. Relying on diet to prevent rejection.
• B. Adhering to immunosuppressant regimen every day as prescribed.
• C. Skipping doses when feeling well.
• D. Taking higher doses if feeling stressed.

Answer: (B)

Maintaining a stable level of immunosuppressant medication is essential after a kidney transplant because these drugs have a narrow therapeutic window and must be taken consistently to keep the immune response suppressed enough to protect the graft without causing toxicity. Taking the medication every day as prescribed ensures trough levels stay within the target range, reducing the risk of acute rejection and graft loss.

Relying on diet cannot substitute for this immune suppression, and skipping doses when you feel well creates subtherapeutic drug levels that can allow rejection to occur. Taking higher doses during stress is not a safe or appropriate strategy; dose changes should only be guided by a clinician based on monitoring results.